Multilayer Networks for Biology

Biological systems are naturally multilayer, with interactions spanning tissues and molecular scales. This work develops multilayer network centrality measures and studies the effect of inter-layer coupling, applying them to uncover molecular mediators of tissue-tissue communication (MultiCens) and to predict cross-tissue hormone-gene relations via balanced word embeddings.

Representative publications (Kumar et al., 2023; Kumar et al., 2019; Jadhav et al., 2022).

References

2023

PLOS Comp. Bio.

MultiCens: Multilayer Network Centrality Measures to Uncover Molecular Mediators of Tissue-Tissue Communication

Tarun Kumar, Ramanathan Sethuraman, Sanga Mitra, and 2 more authors

PLOS Computational Biology, 2023

Bib

@article{kumar2023multicens,
  title = {MultiCens: Multilayer Network Centrality Measures to Uncover Molecular Mediators of Tissue-Tissue Communication},
  author = {Kumar, Tarun and Sethuraman, Ramanathan and Mitra, Sanga and Ravindran, Balaraman and Narayanan, Manikandan},
  journal = {PLOS Computational Biology},
  volume = {19},
  number = {4},
  pages = {e1011022},
  year = {2023},
  publisher = {Public Library of Science},
}

2022

Bioinformatics

Predicting Cross-tissue Hormone-Gene Relations using Balanced Word Embeddings

Aditya Jadhav, Tarun Kumar, Mohit Raghavendra, and 2 more authors

Bioinformatics, 2022

Bib

@article{jadhav2022hormone,
  title = {Predicting Cross-tissue Hormone-Gene Relations using Balanced Word Embeddings},
  author = {Jadhav, Aditya and Kumar, Tarun and Raghavendra, Mohit and L., Tamizhini and Narayanan, Manikandan},
  journal = {Bioinformatics},
  year = {2022},
  publisher = {Oxford University Press},
}

2019

J. Indian Inst. Sci.

Effect of Inter-layer Coupling on Multilayer Network Centrality Measures

Tarun Kumar, Manikandan Narayanan, and Balaraman Ravindran

Journal of the Indian Institute of Science, 2019

Bib

@article{kumar2019interlayer,
  title = {Effect of Inter-layer Coupling on Multilayer Network Centrality Measures},
  author = {Kumar, Tarun and Narayanan, Manikandan and Ravindran, Balaraman},
  journal = {Journal of the Indian Institute of Science},
  volume = {99},
  pages = {237--246},
  year = {2019},
  publisher = {Springer},
}